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الأغشية الحيوية البكتيرية: فهم الهياكل والأدوار (5)
عاهد جمعة الخطيب
باحث علمي في الطب والفلسفة وعلم الاجتماع
(Ahed Jumah Khatib)
2022 / 7 / 8
الطب , والعلوم
يعد تحمل Biofilm إلى ردود الفعل المناعية للمضيف أحد خصائص العدوى المزمنة. تم العثور على الخلايا النواة متعددة الأشكال (PMNs) في العدوى الحادة لتبلعم الكائنات الحية الدقيقة والمواد الغريبة ، كما وجدت أيضًا حول الأغشية الحيوية 54 ، 55 وأظهرت الدراسات التي أجريت على Pseudomonas aeruginosabiofilms أن PMNs يتم تثبيطها بواسطة عامل ينتجه P. aeruginosa ، يسمى rhamnolipids56 ، والجروح: تتعرض الجروح للعدوى التي تعزى إلى فقدان سلامة الجلد التي توفر ظروفًا بيئية جيدة مثل البلل والدفء والمغذيات التي تساعد على الاستعمار الميكروبي. تعمل الالتهابات البكتيرية على منع التئام الجروح عن طريق تحريض تضخم القرحة وتأخير التئامها. أظهرت العديد من الدراسات مؤخرًا أن البكتيريا التي تنمو في الأغشية الحيوية يتم تحديدها في الجروح المزمنة مما يفسر استمرار هذه الجروح.
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